S-sulfhydration of SIRT3 combats BMSC senescence and ameliorates osteoporosis via stabilizing heterochromatic and mitochondrial homeostasis

S-sulfhydration of SIRT3 combats BMSC senescence and ameliorates osteoporosis via stabilizing heterochromatic and mitochondrial homeostasis

Senescence of bone marrow mesenchymal stem cells (BMSCs) is one of the leading causes of osteoporosis. SIRT3, an essential NAD-dependent histone deacetylase, is highly correlated with BMSC senescence-mediated bone degradation and mitochondrial/heterochromatic disturbance. S-sulfhydration of cysteine...

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Bibliographic Details
Main Authors: Fei Liu, Longhui Yuan, Lan Li, Jingchao Yang, Jingping Liu, Younan Chen, Jie Zhang, Yanrong Lu, Yujia Yuan, Jingqiu Cheng
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Pharmacological Research
Subjects:
Cellular senescence
Mitochondria
Antiaging
Reactive oxygen species
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661823001445

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http://www.sciencedirect.com/science/article/pii/S1043661823001445

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