Microbiota-indole 3-propionic acid-brain axis mediates abnormal synaptic pruning of hippocampal microglia and susceptibility to ASD in IUGR offspring

Microbiota-indole 3-propionic acid-brain axis mediates abnormal synaptic pruning of hippocampal microglia and susceptibility to ASD in IUGR offspring

Abstract Background Autism spectrum disorder (ASD) has been associated with intrauterine growth restriction (IUGR), but the underlying mechanisms are unclear. Results We found that the IUGR rat model induced by prenatal caffeine exposure (PCE) showed ASD-like symptoms, accompanied by altered gut mic...

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Bibliographic Details
Main Authors: Tingting Wang, Beidi Chen, Mingcui Luo, Lulu Xie, Mengxi Lu, Xiaoqian Lu, Shuai Zhang, Liyi Wei, Xinli Zhou, Baozhen Yao, Hui Wang, Dan Xu
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Microbiome
Subjects:
Intrauterine growth restriction
Autism spectrum disorder
Gut microbiota
Indole 3-propionic acid
Microglia synaptic pruning
Online Access:https://doi.org/10.1186/s40168-023-01656-1

Internet

https://doi.org/10.1186/s40168-023-01656-1

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