The Role of Na:K:2Cl Cotransporter 1 (NKCC1/SLC12A2) in Dental Epithelium during Enamel Formation in Mice

Na+:K+:2Cl− cotransporters (NKCCs) belong to the SLC12A family of cation-coupled Cl− transporters. We investigated whether enamel-producing mouse ameloblasts express NKCCs. Transcripts for Nkcc1 were identified in the mouse dental epithelium by RT-qPCR and NKCC1 protein was immunolocalized in outer...

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Bibliographic Details
Main Authors: Rozita Jalali, Johannes C. Lodder, Behrouz Zandieh-Doulabi, Dimitra Micha, James E. Melvin, Marcelo A. Catalan, Huibert D. Mansvelder, Pamela DenBesten, Antonius Bronckers
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Physiology
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Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00924/full