Extracellular macrophage migration inhibitory factor (MIF) downregulates adipose hormone-sensitive lipase (HSL) and contributes to obesity

Extracellular macrophage migration inhibitory factor (MIF) downregulates adipose hormone-sensitive lipase (HSL) and contributes to obesity

Attenuation of adipose hormone sensitive lipase (HSL) may impair lipolysis and exacerbate obesity. We investigate the role of cytokine, macrophage migration inhibitory factor (MIF) in regulating adipose HSL and adipocyte hypertrophy. Extracellular MIF downregulates HSL in an autocrine fashion, by ac...

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Bibliographic Details
Main Authors: Liujun Chen, Lisha Li, Donghong Cui, Yiheng Huang, Haibin Tong, Haleh Zabihi, Shuxia Wang, Yadan Qi, Ted Lakowski, Lin Leng, Suixin Liu, Hong Wu, Lawrence H. Young, Richard Bucala, Dake Qi
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Molecular Metabolism
Subjects:
Macrophage migration inhibitory factor (MIF)
Hormone-sensitive lipase (HSL)
Adipose tissue
Obesity
AMP activated protein kinase (AMPK)
c-Jun N-terminal kinase (JNK)
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877823001680

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http://www.sciencedirect.com/science/article/pii/S2212877823001680

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