Metal- and UV- Catalyzed Oxidation Results in Trapped Amyloid-β Intermediates Revealing that Self-Assembly Is Required for Aβ-Induced Cytotoxicity

Metal- and UV- Catalyzed Oxidation Results in Trapped Amyloid-β Intermediates Revealing that Self-Assembly Is Required for Aβ-Induced Cytotoxicity

Summary: Dityrosine (DiY), via the cross-linking of tyrosine residues, is a marker of protein oxidation, which increases with aging. Amyloid-β (Aβ) forms DiY in vitro and DiY-cross-linked Aβ is found in the brains of patients with Alzheimer disease. Metal- or UV- catalyzed oxidation of Aβ42 results...

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Bibliographic Details
Main Authors: Mahmoud B. Maina, Gunasekhar Burra, Youssra K. Al-Hilaly, Kurtis Mengham, Kate Fennell, Louise C. Serpell
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:iScience
Subjects:
Biochemical Mechanism
Molecular Neuroscience
Neurotoxicology
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422030729X

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http://www.sciencedirect.com/science/article/pii/S258900422030729X

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