Astrocytic Nrf2 Mediates the Neuroprotective and Anti-Inflammatory Effects of Nootkatone in an MPTP-Induced Parkinson’s Disease Mouse Model

Astrocytic Nrf2 Mediates the Neuroprotective and Anti-Inflammatory Effects of Nootkatone in an MPTP-Induced Parkinson’s Disease Mouse Model

This study aims to investigate the neuroprotective effects of nootkatone (NKT), a sesquiterpenoid compound isolated from grapefruit, in an MPTP-induced Parkinson’s disease (PD) mouse model. NKT restored MPTP-induced motor impairment and dopaminergic neuronal loss and increased the expression of neur...

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Bibliographic Details
Main Authors: Jung-Eun Park, Yea-Hyun Leem, Jin-Sun Park, Seong-Eun Kim, Hee-Sun Kim
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Antioxidants
Subjects:
Parkinson’s disease
nootkatone
Nrf2
astrocyte
neuroprotection
anti-inflammation
Online Access:https://www.mdpi.com/2076-3921/12/11/1999

Internet

https://www.mdpi.com/2076-3921/12/11/1999

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