SPSB1‐mediated inhibition of TGF‐β receptor‐II impairs myogenesis in inflammation

SPSB1‐mediated inhibition of TGF‐β receptor‐II impairs myogenesis in inflammation

Abstract Background Sepsis‐induced intensive care unit‐acquired weakness (ICUAW) features profound muscle atrophy and attenuated muscle regeneration related to malfunctioning satellite cells. Transforming growth factor beta (TGF‐β) is involved in both processes. We uncovered an increased expression...

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Bibliographic Details
Main Authors: Yi Li, Niklas Dörmann, Björn Brinschwitz, Melanie Kny, Elisa Martin, Kirsten Bartels, Ning Li, Priyanka Voori Giri, Stefan Schwanz, Michael Boschmann, Susanne Hille, Britta Fielitz, Tobias Wollersheim, Julius Grunow, Stephan B. Felix, Steffen Weber‐Carstens, Friedrich C. Luft, Oliver J. Müller, Jens Fielitz
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Critical illness myopathy
Sepsis
Inflammation‐induced muscle atrophy
SPSB1
TGFβ receptor II
Myogenic differentiation
Online Access:https://doi.org/10.1002/jcsm.13252

Internet

https://doi.org/10.1002/jcsm.13252

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