Characterization of cooperative PS-oligo activation of human TLR9

Characterization of cooperative PS-oligo activation of human TLR9

Single-stranded phosphorothioate oligonucleotides (PS-oligos) can activate TLR9, leading to an innate immune response. This can occur with PS-oligos containing unmethylated CpG sites, the canonical motif, or PS-oligos that do not contain those motifs (non-CpG). Structural evidence shows that TLR9 co...

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Bibliographic Details
Main Authors: Adam J. Pollak, Luyi Zhao, Stanley T. Crooke
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Oligonucleotides: Therapies and Applications
TLR9
PS-ASO
CpG
innate immunity
receptor cooperativity
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253123002202

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http://www.sciencedirect.com/science/article/pii/S2162253123002202

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