In vivo efficacy of HDL-like nanolipid particles containing multivalent peptide mimetics of apolipoprotein A-I[S]

In vivo efficacy of HDL-like nanolipid particles containing multivalent peptide mimetics of apolipoprotein A-I[S]

We have observed that molecular constructs based on multiple apoA-I mimetic peptides attached to a branched scaffold display promising anti-atherosclerosis functions in vitro. Building on these promising results, we now describe chronic in vivo studies to assess anti-atherosclerotic efficacy of HDL-...

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Bibliographic Details
Main Authors: Yannan Zhao, Audrey S. Black, David J. Bonnet, Bruce E. Maryanoff, Linda K. Curtiss, Luke J. Leman, M. Reza Ghadiri
Format: Article
Language:English
Published: Elsevier 2014-10-01
Series:Journal of Lipid Research
Subjects:
cholesterol
α-helix
atherosclerosis
nanoparticle
amphiphilic
drug development
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520350094

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http://www.sciencedirect.com/science/article/pii/S0022227520350094

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