Pharmacokinetics and biodistribution of a human monoclonal antibody to oxidized LDL in cynomolgus monkey using PET imaging.

Pharmacokinetics and biodistribution of a human monoclonal antibody to oxidized LDL in cynomolgus monkey using PET imaging.

Oxidized low-density lipoprotein (LDL) plays an essential role in the pathogenesis of atherosclerosis. The purpose of this study was to characterize the pharmacokinetics (PK) of a human recombinant IgG1 antibody to oxidized LDL (anti-oxLDL) in cynomolgus monkey. The tissue biodistribution of anti-ox...

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Bibliographic Details
Main Authors: Amrita V Kamath, Simon P Williams, Sherry Bullens, Kyra J Cowan, Yvonne Stenberg, Simon R Cherry, Stephen Rendig, David L Kukis, Chris Griesemer, Lisa A Damico-Beyer, Stuart Bunting
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3444451?pdf=render

Internet

http://europepmc.org/articles/PMC3444451?pdf=render

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