Regional Variation in Epidermal Susceptibility to UV-Induced Carcinogenesis Reflects Proliferative Activity of Epidermal Progenitors

Regional Variation in Epidermal Susceptibility to UV-Induced Carcinogenesis Reflects Proliferative Activity of Epidermal Progenitors

Summary: To better understand the influence of ultraviolet (UV) irradiation on the initial steps of skin carcinogenesis, we examine patches of labeled keratinocytes as a proxy for clones in the interfollicular epidermis (IFE) and measure their size variation upon UVB irradiation. Multicolor lineage...

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Bibliographic Details
Main Authors: Edwige Roy, Ho Yi Wong, Rehan Villani, Thomas Rouille, Basit Salik, Seen Ling Sim, Valentine Murigneux, Mitchell S. Stark, J. Lynn Fink, H. Peter Soyer, Graeme Walker, J. Guy Lyons, Nicholas Saunders, Kiarash Khosrotehrani
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Cell Reports
Subjects:
multicolor lineage tracing
basal cell carcinoma
non-melanoma skin cancer
ultra-violet radiation
hair follicles
field carcinogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720306720

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http://www.sciencedirect.com/science/article/pii/S2211124720306720

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