L1 Cell Adhesion Molecule-Specific Chimeric Antigen Receptor-Redirected Human T Cells Exhibit Specific and Efficient Antitumor Activity against Human Ovarian Cancer in Mice.

L1 Cell Adhesion Molecule-Specific Chimeric Antigen Receptor-Redirected Human T Cells Exhibit Specific and Efficient Antitumor Activity against Human Ovarian Cancer in Mice.

New therapeutic modalities are needed for ovarian cancer, the most lethal gynecologic malignancy. Recent clinical trials have demonstrated the impressive therapeutic potential of adoptive therapy using chimeric antigen receptor (CAR)-redirected T cells to target hematological cancers, and emerging s...

Full description

Bibliographic Details
Main Authors: Hao Hong, Christine E Brown, Julie R Ostberg, Saul J Priceman, Wen-Chung Chang, Lihong Weng, Paul Lin, Mark T Wakabayashi, Michael C Jensen, Stephen J Forman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4711972?pdf=render

Internet

http://europepmc.org/articles/PMC4711972?pdf=render

Similar Items