Mesenchymal Stromal Cells Overexpressing Farnesoid X Receptor Exert Cardioprotective Effects Against Acute Ischemic Heart Injury by Binding Endogenous Bile Acids

Mesenchymal Stromal Cells Overexpressing Farnesoid X Receptor Exert Cardioprotective Effects Against Acute Ischemic Heart Injury by Binding Endogenous Bile Acids

Abstract Bile acid metabolites have been increasingly recognized as pleiotropic signaling molecules that regulate cardiovascular functions, but their role in mesenchymal stromal cells (MSC)‐based therapy has never been investigated. It is found that overexpression of farnesoid X receptor (FXR), a ma...

Full description

Bibliographic Details
Main Authors: Yunlong Xia, Xinyue Xu, Yongzhen Guo, Chen Lin, Xiaoming Xu, Fuyang Zhang, Miaomiao Fan, Tingting Qi, Congye Li, Guangyu Hu, Lu Peng, Shan Wang, Ling Zhang, Chunxu Hai, Rui Liu, Wenjun Yan, Ling Tao
Format: Article
Language:English
Published: Wiley 2022-08-01
Series:Advanced Science
Subjects:
bile acids
farnesoid X receptor
ischemic heart injury
mesenchymal stromal cells
paracrine angiogenesis
Online Access:https://doi.org/10.1002/advs.202200431

Internet

https://doi.org/10.1002/advs.202200431

Similar Items