Probenecid-Blocked Pannexin-1 Channel Protects Against Early Brain Injury via Inhibiting Neuronal AIM2 Inflammasome Activation After Subarachnoid Hemorrhage

Probenecid-Blocked Pannexin-1 Channel Protects Against Early Brain Injury via Inhibiting Neuronal AIM2 Inflammasome Activation After Subarachnoid Hemorrhage

AimPrevious studies have proved that inhibiting inflammasome activation provides neuroprotection against early brain injury (EBI) after subarachnoid hemorrhage (SAH), which is mainly focused on the microglial inflammatory response, but the potential role of neuronal inflammasome activation in EBI ha...

Full description

Bibliographic Details
Main Authors: Yonghe Zheng, Wenwen Tang, Hanhai Zeng, Yucong Peng, Xiaobo Yu, Feng Yan, Shenglong Cao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Neurology
Subjects:
AIM2 inflammasome
early brain injury
neurons
pannexin-1
subarachnoid hemorrhage
probenecid
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2022.854671/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2022.854671/full

Similar Items