Mechanisms of unconventional CD8 Tc2 lymphocyte induction in allergic contact dermatitis: Role of H3/H4 histamine receptors

Mechanisms of unconventional CD8 Tc2 lymphocyte induction in allergic contact dermatitis: Role of H3/H4 histamine receptors

Histamine (HA) is a potent mediator that plays a central role in inflammation and allergy, acting through four G-protein-coupled receptors (i.e. H1–H4). HA is an accepted promoter of type 2 immunity in CD4+ T cells during hypersensitivity. Previously, we demonstrated that HA can promote antigen cros...

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Bibliographic Details
Main Authors: Julieta Alcain, Alejandra del Pilar Infante Cruz, Gabriela Barrientos, Silvia Vanzulli, Gabriela Salamone, Mónica Vermeulen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
H4/H3 histamine receptors
allergy contact dermatitis
non-conventional CD8+ lymphocytes
immunoregulation
dendritic cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.999852/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.999852/full

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