Insufficient phosphorylation of STAT5 in Tregs inhibits the expression of BLIMP-1 but not IRF4, reduction the proportion of Tregs in pediatric aplastic anemia

Insufficient phosphorylation of STAT5 in Tregs inhibits the expression of BLIMP-1 but not IRF4, reduction the proportion of Tregs in pediatric aplastic anemia

Deficiency in regulatory T cells (Tregs) is an important mechanism underlying the pathogenesis of pediatric aplastic anemia, but its specific mechanism is unclear. In our study, we aimed to investigate whether IL-2/STAT5 can regulate the proliferation of Tregs in aplastic anemia (AA) by regulating t...

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Bibliographic Details
Main Authors: Lifen Huang, Junbin Huang, Nannan Tang, Hongman Xue, Shaofen Lin, Su Liu, Qihui Chen, Yinsi Lu, Qian Liang, Yun Wang, Qingqing Zhu, Guoxing Zheng, Yun Chen, Chengming Zhu, Chun Chen
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Heliyon
Subjects:
Pediatric aplastic anemia
Regulatory T cells (tregs)
B lymphocyte-induced mature protein-1 (BLIMP-1)
Interferon regulatory factor 4 (IRF4)
Signal transducer and activator of transcription 5 (STAT5)
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024027622

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