Identification of bi-allelic KIF9 loss-of-function variants contributing to asthenospermia and male infertility in two Chinese families

Identification of bi-allelic KIF9 loss-of-function variants contributing to asthenospermia and male infertility in two Chinese families

IntroductionAsthenozoospermia (AZS) is a leading cause of male infertility, affecting an estimated 18% of infertile patients. Kinesin proteins function as molecular motors capable of moving along microtubules. The highly conserved kinesin family member 9 (KIF9) localizes to the central microtubule p...

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Bibliographic Details
Main Authors: Zhixiang Meng, Qingxia Meng, Tingting Gao, Hui Zhou, Jiajia Xue, Hong Li, Yibo Wu, Jinxing Lv
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Endocrinology
Subjects:
male infertility
asthenozoospermia
KIF9
HYDIN
flagellum
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.1091107/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.1091107/full

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