KRAS mutant lung cancer: progress thus far on an elusive therapeutic target
AbstractThe KRAS mutation remains the most common driver mutation in patients with non‐small cell lung cancer (NSCLC) and confers a poor prognosis. Thus far, efforts to target this mutation over the last two decades have been unsuccessful. Over the past 5 years, many efforts to develop drugs that ta...
Main Authors: | Saveri Bhattacharya, Mark A. Socinski, Timothy F. Burns |
---|---|
Format: | Article |
Language: | English |
Published: |
Wiley
2015-12-01
|
Series: | Clinical and Translational Medicine |
Subjects: | |
Online Access: | https://doi.org/10.1186/s40169-015-0075-0 |
Similar Items
-
Efficacy of immunotherapy in KRAS-mutant advanced NSCLC: A real-world study in a Chinese population
by: Lixiu Peng, et al.
Published: (2023-01-01) -
Profiling oncogenic KRAS mutant drugs with a cell-based Lumit p-ERK immunoassay
by: Matthew Swiatnicki, et al.
Published: (2022-06-01) -
Characterization With KRAS Mutant Is a Critical Determinant in Immunotherapy and Other Multiple Therapies for Non-Small Cell Lung Cancer
by: Mo Shen, et al.
Published: (2022-01-01) -
Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy
by: Ke Xu, et al.
Published: (2019-04-01) -
Targeted Therapies for Kirsten Rat Sarcoma (KRAS) G12C Mutant Metastatic Non-Small-Cell Lung Cancers
by: Cian O’Leary, et al.
Published: (2023-11-01)