Sex-specific epigenetics drive low GPER expression in gastrointestinal smooth muscles in type 2 diabetic mice

Sex-specific epigenetics drive low GPER expression in gastrointestinal smooth muscles in type 2 diabetic mice

Abstract Type 2 diabetes mellitus (T2D) causes gastroparesis, delayed intestinal transit, and constipation, for unknown reasons. Complications are predominant in women than men (particularly pregnant and postmenopausal women), suggesting a female hormone-mediated mechanism. Low G-protein coupled est...

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Bibliographic Details
Main Authors: Aliyu Muhammad, Juanita C. Hixon, Abdurrahman Pharmacy Yusuf, Jatna I. Rivas Zarete, India Johnson, Jamial Miller, Benjamin Adu-Addai, Clayton Yates, Sunila Mahavadi
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Subjects:
GPER
Epigenomics
Type 2 diabetes
Smooth muscle
Sex
Online Access:https://doi.org/10.1038/s41598-024-54213-7

Internet

https://doi.org/10.1038/s41598-024-54213-7

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