Stellettin B Sensitizes Glioblastoma to DNA‐Damaging Treatments by Suppressing PI3K‐Mediated Homologous Recombination Repair

Stellettin B Sensitizes Glioblastoma to DNA‐Damaging Treatments by Suppressing PI3K‐Mediated Homologous Recombination Repair

Abstract Glioblastoma (GBM) is the most aggressive type of cancer. Its current first‐line postsurgery regimens are radiotherapy and temozolomide (TMZ) chemotherapy, both of which are DNA damage‐inducing therapies but show very limited efficacy and a high risk of resistance. There is an urgent need t...

Full description

Bibliographic Details
Main Authors: Xin Peng, Shaolu Zhang, Yingying Wang, Zhicheng Zhou, Zixiang Yu, Zhenxing Zhong, Liang Zhang, Zhe‐Sheng Chen, Francois X. Claret, Moshe Elkabets, Feng Wang, Fan Sun, Ran Wang, Han Liang, Hou‐Wen Lin, Dexin Kong
Format: Article
Language:English
Published: Wiley 2023-01-01
Series:Advanced Science
Subjects:
DNA‐damaging treatment
glioblastoma
homologous recombination repair
PI3K
stellettin B
Online Access:https://doi.org/10.1002/advs.202205529

Internet

https://doi.org/10.1002/advs.202205529

Similar Items