Unraveling the Structural Changes in the DNA-Binding Region of Tumor Protein p53 (<i>TP53</i>) upon Hotspot Mutation p53 Arg248 by Comparative Computational Approach

Unraveling the Structural Changes in the DNA-Binding Region of Tumor Protein p53 (<i>TP53</i>) upon Hotspot Mutation p53 Arg248 by Comparative Computational Approach

The vital tissue homeostasis regulator p53 forms a tetramer when it binds to DNA and regulates the genes that mediate essential biological processes such as cell-cycle arrest, senescence, DNA repair, and apoptosis. Missense mutations in the core DNA-binding domain (109–292) simultaneously cause the...

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Bibliographic Details
Main Authors: Ambritha Balasundaram, C. George Priya Doss
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
<i>p53</i>
R248
human cancer
pathogenicity
<i>p53</i>–DNA interaction
molecular dynamics simulation
Online Access:https://www.mdpi.com/1422-0067/23/24/15499

Internet

https://www.mdpi.com/1422-0067/23/24/15499

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