A Curcumin Derivative, 2,6-Bis(2,5-dimethoxybenzylidene)-cyclohexanone (BDMC33) Attenuates Prostaglandin E2 Synthesis via Selective Suppression of Cyclooxygenase-2 in IFN-g/LPS-Stimulated Macrophages

A Curcumin Derivative, 2,6-Bis(2,5-dimethoxybenzylidene)-cyclohexanone (BDMC33) Attenuates Prostaglandin E2 Synthesis via Selective Suppression of Cyclooxygenase-2 in IFN-g/LPS-Stimulated Macrophages

Our preliminary screening had shown that the curcumin derivative [2,6-bis(2,5-dimethoxybenzylidene)cyclohexanone] or BDMC33 exhibited improved anti-inflammatory activity by inhibiting nitric oxide synthesis in activated macrophage cells. In this study, we further investigated the anti-inflammatory p...

Full description

Bibliographic Details
Main Authors: Syahida Ahmad, Nordin Haji Lajis, Khozirah Shaari, Ka-Heng Lee, Faridah Abas, Noorjahan Banu Mohamed Alitheen
Format: Article
Language:English
Published: MDPI AG 2011-11-01
Series:Molecules
Subjects:
anti-inflammatory
BDMC33
cyclooxygenase
PGE2
RAW264.7
Online Access:http://www.mdpi.com/1420-3049/16/11/9728/

Internet

http://www.mdpi.com/1420-3049/16/11/9728/

Similar Items