Increased Cleavage of Japanese Encephalitis Virus prM Protein Promotes Viral Replication but Attenuates Virulence

ABSTRACT In flavivirus, the furin-mediated cleavage of prM is mandatory to produce infectious particles, and the immature particles containing uncleaved prM cannot undergo membrane fusion and release to the extracellular environment. However, the detailed relationship between viral replication or pa...

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Bibliographic Details
Main Authors: Junyao Xiong, Mengxue Yan, Shuo Zhu, Bohan Zheng, Ning Wei, Lingen Yang, Youhui Si, Shengbo Cao, Jing Ye
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:Microbiology Spectrum
Subjects:
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01417-22