Human dyskerin binds to cytoplasmic H/ACA-box-containing transcripts affecting nuclear hormone receptor dependence

Human dyskerin binds to cytoplasmic H/ACA-box-containing transcripts affecting nuclear hormone receptor dependence

Abstract Background Dyskerin is a nuclear protein involved in H/ACA box snoRNA-guided uridine modification of RNA. In humans, its defective function is associated with cancer development and induces specific post-transcriptional alterations of gene expression. In this study, we seek to unbiasedly id...

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Bibliographic Details
Main Authors: Federico Zacchini, Giulia Venturi, Veronica De Sanctis, Roberto Bertorelli, Claudio Ceccarelli, Donatella Santini, Mario Taffurelli, Marianna Penzo, Davide Treré, Alberto Inga, Erik Dassi, Lorenzo Montanaro
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Genome Biology
Subjects:
DKC1
intron retention
RNA binding
Post-transcriptional control
Breast cancer
Online Access:https://doi.org/10.1186/s13059-022-02746-3

Internet

https://doi.org/10.1186/s13059-022-02746-3

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