Pharmacological Activation of Potassium Channel Kv11.1 with NS1643 Attenuates Triple Negative Breast Cancer Cell Migration by Promoting the Dephosphorylation of Caveolin-1

Pharmacological Activation of Potassium Channel Kv11.1 with NS1643 Attenuates Triple Negative Breast Cancer Cell Migration by Promoting the Dephosphorylation of Caveolin-1

The prevention of metastasis is a central goal of cancer therapy. Caveolin-1 (Cav-1) is a structural membrane and scaffolding protein shown to be a key regulator of late-stage breast cancer metastasis. However, therapeutic strategies targeting Cav-1 are still lacking. Here, we demonstrate that the p...

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Bibliographic Details
Main Authors: Ying Jiang, Vitalyi Senyuk, Ke Ma, Hui Chen, Xiang Qin, Shun Li, Yiyao Liu, Saverio Gentile, Richard D. Minshall
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cells
Subjects:
calpain
PTP1B
β-catenin
R-cadherin
adherens junction
focal adhesion complex
Online Access:https://www.mdpi.com/2073-4409/11/15/2461

Internet

https://www.mdpi.com/2073-4409/11/15/2461

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