Endosomal Escape and Nuclear Localization: Critical Barriers for Therapeutic Nucleic Acids

Endosomal Escape and Nuclear Localization: Critical Barriers for Therapeutic Nucleic Acids

Therapeutic nucleic acids (TNAs) including antisense oligonucleotides (ASOs) and small interfering RNA (siRNA) have emerged as promising treatment strategies for a wide variety of diseases, offering the potential to modulate gene expression with a high degree of specificity. These small, synthetic n...

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Bibliographic Details
Main Authors: Randall Allen, Toshifumi Yokota
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Molecules
Subjects:
therapeutic nucleic acids
antisense oligonucleotides
small interfering RNA
endosomal escape
nuclear localization
drug delivery
Online Access:https://www.mdpi.com/1420-3049/29/24/5997

Internet

https://www.mdpi.com/1420-3049/29/24/5997

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