Treatment of Dystrophic <i>mdx </i>Mice with an ADAMTS-5 Specific Monoclonal Antibody Increases the Ex Vivo Strength of Isolated Fast Twitch Hindlimb Muscles

Treatment of Dystrophic <i>mdx </i>Mice with an ADAMTS-5 Specific Monoclonal Antibody Increases the Ex Vivo Strength of Isolated Fast Twitch Hindlimb Muscles

Aberrant extracellular matrix synthesis and remodeling contributes to muscle degeneration and weakness in Duchenne muscular dystrophy (DMD). ADAMTS-5, a secreted metalloproteinase with catalytic activity against versican, is implicated in myogenesis and inflammation. Here, using the <i>mdx<...

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Bibliographic Details
Main Authors: Alex B. Addinsall, Leonard G. Forgan, Natasha L. McRae, Rhys W. Kelly, Penny L. McDonald, Bryony McNeill, Daniel R. McCulloch, Nicole Stupka
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Biomolecules
Subjects:
adamts-5
contractile function
desmin
duchenne muscular dystrophy
mdx mouse
myogenesis
skeletal muscle
versican
versikine
Online Access:https://www.mdpi.com/2218-273X/10/3/416

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https://www.mdpi.com/2218-273X/10/3/416

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