Synthesis and Inhibitory Effect of Some Indole‐Pyrimidine Based Hybrid Heterocycles on α‐Glucosidase and α‐Amylase as Potential Hypoglycemic Agents

Synthesis and Inhibitory Effect of Some Indole‐Pyrimidine Based Hybrid Heterocycles on α‐Glucosidase and α‐Amylase as Potential Hypoglycemic Agents

Abstract The Michael addition reaction of barbituric acid with chalcones incorporating the indole scaffold was achieved by using a highly efficient bimetallic Iron–palladium catalyst in the presence of acetylacetone (acac). This catalytic approach produced the desired products in a simple operation...

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Bibliographic Details
Main Authors: Prof. Dr. Farid A. Badria, Saleh Atef, Prof. Dr. Abdullah Mohammed Al‐Majid, M. Ali, Dr. Yaseen A. M. M. Elshaier, Dr. Hazem A. Ghabbour, Mohammad Shahidul Islam, Dr. Assem Barakat
Format: Article
Language:English
Published: Wiley-VCH 2019-10-01
Series:ChemistryOpen
Subjects:
bimetallic catalysis
Lewis acid
Michael addition
indoles
barbituric acid
α-amylase
Online Access:https://doi.org/10.1002/open.201900240

Internet

https://doi.org/10.1002/open.201900240

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