A moderate reduction in extracellular pH protects macrophages against apoptosis induced by oxidized low density lipoprotein

A moderate reduction in extracellular pH protects macrophages against apoptosis induced by oxidized low density lipoprotein

We investigated the effect of pH on macrophage apoptosis induced by oxidized low density lipoprotein (OxLDL), as human atherosclerotic lesions have regions of low pH. Hydroperoxide-rich and oxysterol-rich LDL caused 38% and 74% apoptosis of J774 macrophages, respectively, at 24 h, as measured by the...

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Bibliographic Details
Main Authors: Andrew B. Gerry, David S. Leake
Format: Article
Language:English
Published: Elsevier 2008-04-01
Series:Journal of Lipid Research
Subjects:
atherosclerosis
inflammation
monocyte
necrosis
scavenger receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520423910

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http://www.sciencedirect.com/science/article/pii/S0022227520423910

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