FGF2 overrides key pro-fibrotic features of bone marrow stromal cells isolated from Modic type 1 change patients

FGF2 overrides key pro-fibrotic features of bone marrow stromal cells isolated from Modic type 1 change patients

Extensive extracellular matrix production and increased cell-matrix adhesion by bone marrow stromal cells (BMSCs) are hallmarks of fibrotic alterations in the vertebral bone marrow known as Modic type 1 changes (MC1). MC1 are associated with non-specific chronic low-back pain. To identify treatment...

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Bibliographic Details
Main Authors: I Heggli, U Blache, N Herger, T Mengis, PK Jaeger, R Schuepbach, N Farshad-Amacker, F Brunner, JG Snedeker, M Farshad, O Distler, S Dudli
Format: Article
Language:English
Published: AO Research Institute Davos 2022-10-01
Series:European Cells & Materials
Subjects:
bone marrow stromal cells
fibroblast growth factor 2
basic fibroblast growth factor
modic changes
fibrosis
extracellular matrix
Online Access:https://www.ecmjournal.org/papers/vol044/pdf/v044a07.pdf

Internet

https://www.ecmjournal.org/papers/vol044/pdf/v044a07.pdf

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