Insulin-like growth factor 2 promotes osteoclastogenesis increasing inflammatory cytokine levels under hypoxia

Insulin-like growth factor 2 promotes osteoclastogenesis increasing inflammatory cytokine levels under hypoxia

Osteoporosis is caused by an imbalance in bone remodeling due to abnormal osteoclast (OC) formation and activation. Hypoxia at the site of inflammation promotes OC formation and activation in various species, including humans. We previously reported that insulin-like growth factor 2 (IGF2) plays an...

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Detalhes bibliográficos
Main Authors: Takao Kondo, Hiromasa Aoki, Yuto Otsuka, Yohei Kawaguchi, Yuko Waguri-Nagaya, Mineyoshi Aoyama
Formato: Artigo
Idioma:English
Publicado em: Elsevier 2022-07-01
Colecção:Journal of Pharmacological Sciences
Assuntos:
Osteoclast
Hypoxia
IGF2
Akt
NF-κB
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1347861322000305

Internet

http://www.sciencedirect.com/science/article/pii/S1347861322000305

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