Astroglia-Derived BDNF and MSK-1 Mediate Experience- and Diet-Dependent Synaptic Plasticity

Astroglia-Derived BDNF and MSK-1 Mediate Experience- and Diet-Dependent Synaptic Plasticity

Experience- and diet-dependent regulation of synaptic plasticity can underlie beneficial effects of active lifestyle on the aging brain. Our previous results demonstrate a key role for brain-derived neurotrophic factor (BDNF) and MSK1 kinase in experience-related homeostatic synaptic scaling. Astrog...

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Bibliographic Details
Main Authors: Ulyana Lalo, Alexander Bogdanov, Guy W. Moss, Yuriy Pankratov
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Brain Sciences
Subjects:
aging
dendritic spines
synaptic strength
glia-neuron interactions
ion conductance microscopy
synaptic scaling
Online Access:https://www.mdpi.com/2076-3425/10/7/462

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https://www.mdpi.com/2076-3425/10/7/462

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