A <named-content content-type="genus-species">Trypanosoma brucei</named-content> ORFeome-Based Gain-of-Function Library Identifies Genes That Promote Survival during Melarsoprol Treatment

A <named-content content-type="genus-species">Trypanosoma brucei</named-content> ORFeome-Based Gain-of-Function Library Identifies Genes That Promote Survival during Melarsoprol Treatment

ABSTRACT Trypanosoma brucei is an early branching protozoan parasite that causes human and animal African trypanosomiasis. Forward genetics approaches are powerful tools for uncovering novel aspects of trypanosomatid biology, pathogenesis, and therapeutic approaches against trypanosomiasis. Here, we...

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Bibliographic Details
Main Authors: McKenzie Carter, Stephanie Gomez, Sam Gritz, Stephen Larson, Eugenia Silva-Herzog, Hee-Sook Kim, Danae Schulz, Galadriel Hovel-Miner
Format: Article
Language:English
Published: American Society for Microbiology 2020-10-01
Series:mSphere
Subjects:
forward genetics
ORFeome
Trypanosoma
drug resistance mechanisms
parasitology
redox signaling
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00769-20

Internet

https://journals.asm.org/doi/10.1128/mSphere.00769-20

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