Amphiphilic “Like-A-Brush” Oligonucleotide Conjugates with Three Dodecyl Chains: Self-Assembly Features of Novel Scaffold Compounds for Nucleic Acids Delivery

Amphiphilic “Like-A-Brush” Oligonucleotide Conjugates with Three Dodecyl Chains: Self-Assembly Features of Novel Scaffold Compounds for Nucleic Acids Delivery

The conjugation of lipophilic groups to oligonucleotides is a promising approach for improving nucleic acid-based therapeutics’ intracellular delivery. Lipid oligonucleotide conjugates can self-aggregate in aqueous solution, which gains much attention due to the formation of micellar particles suita...

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Bibliographic Details
Main Authors: Anna S. Pavlova, Ilya S. Dovydenko, Maxim S. Kupryushkin, Alina E. Grigor’eva, Inna A. Pyshnaya, Dmitrii V. Pyshnyi
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Nanomaterials
Subjects:
lipid conjugates
amphiphilic oligonucleotides
self-assembly
phosphoryl guanidines
nucleic acid delivery
Online Access:https://www.mdpi.com/2079-4991/10/10/1948

Internet

https://www.mdpi.com/2079-4991/10/10/1948

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