HLA-DQA1 and HLA-DQB1 Alleles, Conferring Susceptibility to Celiac Disease and Type 1 Diabetes, Are More Expressed Than Non-Predisposing Alleles and Are Coordinately Regulated

HLA-DQA1 and HLA-DQB1 Alleles, Conferring Susceptibility to Celiac Disease and Type 1 Diabetes, Are More Expressed Than Non-Predisposing Alleles and Are Coordinately Regulated

HLA DQA1*05 and DQB1*02 alleles encoding the DQ2.5 molecule and HLA DQA1*03 and DQB1*03 alleles encoding DQ8 molecules are strongly associated with celiac disease (CD) and type 1 diabetes (T1D), two common autoimmune diseases (AD). We previously demonstrated that DQ2.5 genes showed a higher expressi...

Full description

Bibliographic Details
Main Authors: Federica Farina, Stefania Picascia, Laura Pisapia, Pasquale Barba, Serena Vitale, Adriana Franzese, Enza Mozzillo, Carmen Gianfrani, Giovanna Del Pozzo G
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Cells
Subjects:
autoimmunity
risk genes
expression
regulation
Online Access:https://www.mdpi.com/2073-4409/8/7/751

Internet

https://www.mdpi.com/2073-4409/8/7/751

Similar Items