Effect of erythromycin on mortality and the host response in critically ill patients with sepsis: a target trial emulation

Effect of erythromycin on mortality and the host response in critically ill patients with sepsis: a target trial emulation

Abstract Background Immunomodulatory therapies that improve the outcome of sepsis are not available. We sought to determine whether treatment of critically ill patients with sepsis with low-dose erythromycin—a macrolide antibiotic with broad immunomodulatory effects—decreased mortality and ameliorat...

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Bibliographic Details
Main Authors: Tom D. Y. Reijnders, Hessel Peters-Sengers, Lonneke A. van Vught, Fabrice Uhel, Marc J. M. Bonten, Olaf L. Cremer, Marcus J. Schultz, Martijn M. Stuiver, Tom van der Poll, the MARS consortium
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Critical Care
Subjects:
Sepsis
Critically ill
Macrolides
Erythromycin
Immunomodulation
Propensity score
Online Access:https://doi.org/10.1186/s13054-022-04016-x

Internet

https://doi.org/10.1186/s13054-022-04016-x

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