FcγRIIIb Restricts Antibody-Dependent Destruction of Cancer Cells by Human Neutrophils

FcγRIIIb Restricts Antibody-Dependent Destruction of Cancer Cells by Human Neutrophils

The function of the low-affinity IgG-receptor FcγRIIIb (CD16b), which is uniquely and abundantly expressed on human granulocytes, is not clear. Unlike the other Fcγ receptors (FcγR), it is a glycophosphatidyl inositol (GPI) -anchored molecule and does not have intracellular signaling motifs. Neverth...

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Bibliographic Details
Main Authors: Louise W. Treffers, Michel van Houdt, Christine W. Bruggeman, Marieke H. Heineke, Xi Wen Zhao, Joris van der Heijden, Sietse Q. Nagelkerke, Paul J. J. H. Verkuijlen, Judy Geissler, Suzanne Lissenberg-Thunnissen, Thomas Valerius, Matthias Peipp, Katka Franke, Robin van Bruggen, Taco W. Kuijpers, Marjolein van Egmond, Gestur Vidarsson, Hanke L. Matlung, Timo K. van den Berg
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
FcγRIIIb
neutrophil
ADCC
cancer
granulocyte
Fc-receptor
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03124/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.03124/full

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