Impact of rare and common genetic variation in the interleukin-1 pathway on human cytokine responses

Impact of rare and common genetic variation in the interleukin-1 pathway on human cytokine responses

Abstract Background The interleukin (IL)-1 pathway is primarily associated with innate immunological defense and plays a major role in the induction and regulation of inflammation. Both common and rare genetic variation in this pathway underlies various inflammation-mediated diseases, but the role o...

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Bibliographic Details
Main Authors: Rosanne C. van Deuren, Peer Arts, Giulio Cavalli, Martin Jaeger, Marloes Steehouwer, Maartje van de Vorst, Christian Gilissen, Leo A. B. Joosten, Charles A. Dinarello, Musa M. Mhlanga, Vinod Kumar, Mihai G. Netea, Frank L. van de Veerdonk, Alexander Hoischen
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Genome Medicine
Subjects:
Rare variants
SKAT
Common variants
Region-based analysis
Interleukin-1 pathway
Immunological mechanisms
Online Access:https://doi.org/10.1186/s13073-021-00907-w

Internet

https://doi.org/10.1186/s13073-021-00907-w

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