Exosc9 Initiates SUMO-Dependent lncRNA TERRA Degradation to Impact Telomeric Integrity in Endocrine Therapy Insensitive Hormone Receptor-Positive Breast Cancer

Exosc9 Initiates SUMO-Dependent lncRNA TERRA Degradation to Impact Telomeric Integrity in Endocrine Therapy Insensitive Hormone Receptor-Positive Breast Cancer

Long, noncoding RNAs (lncRNAs) are indispensable for normal cell physiology and, consequently, are tightly regulated in human cells. Yet, unlike mRNA, substantially less is known about the mechanisms for lncRNA degradation. It is important to delineate the regulatory control of lncRNA degradation, p...

Full description

Bibliographic Details
Main Authors: Maram Quttina, Kacie D. Waiters, Ashfia Fatima Khan, Samaneh Karami, Anthony S. Peidl, Mariam Funmi Babajide, Justus Pennington, Fatima A. Merchant, Tasneem Bawa-Khalfe
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Cells
Subjects:
Exosc9
HP1-alpha
TERRA
SUMO
telomeric R-loops
Online Access:https://www.mdpi.com/2073-4409/12/20/2495

Internet

https://www.mdpi.com/2073-4409/12/20/2495

Similar Items