Inhibitions of monoamine oxidases by ferulic acid hydrazide derivatives: synthesis, biochemistry, and computational evaluation

Inhibitions of monoamine oxidases by ferulic acid hydrazide derivatives: synthesis, biochemistry, and computational evaluation

Abstract Monoamine oxidases (MAOs) regulate neurotransmitters, and changes in their regulation lead to neurogenerative diseases (NDs). Therefore, MAO inhibitors are used to treat NDs. Ferulic acid, a phenolic compound found in various plant species, has been demonstrated to have a variety of biologi...

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Bibliographic Details
Main Authors: Arshida Thottile Peedikayil, Jiseong Lee, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Mohamed E. Shaker, Samy Selim, Sunil Kumar, Sanal Dev, Hoon Kim, Bijo Mathew
Format: Article
Language:English
Published: SpringerOpen 2023-10-01
Series:Applied Biological Chemistry
Subjects:
Ferulic acid
Monoamine oxidase
Kinetics
Reversibility
Molecular docking
Molecular dynamics
Online Access:https://doi.org/10.1186/s13765-023-00823-0

Internet

https://doi.org/10.1186/s13765-023-00823-0

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