New Enhancing MRI Lesions Associate with IL-17, Neutrophil Degranulation and Integrin Microparticles: Multi-Omics Combined with Frequent MRI in Multiple Sclerosis

New Enhancing MRI Lesions Associate with IL-17, Neutrophil Degranulation and Integrin Microparticles: Multi-Omics Combined with Frequent MRI in Multiple Sclerosis

Background: Blood–barrier (BBB) breakdown and active inflammation are hallmarks of relapsing multiple sclerosis (RMS), but the molecular events contributing to the development of new lesions are not well explored. Leaky endothelial junctions are associated with increased production of endothelial-de...

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Bibliographic Details
Main Authors: Zsolt Illes, Malene Møller Jørgensen, Rikke Bæk, Lisa-Marie Bente, Jørgen T. Lauridsen, Kirsten H. Hyrlov, Christopher Aboo, Jan Baumbach, Tim Kacprowski, Francois Cotton, Charles R. G. Guttmann, Allan Stensballe
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Biomedicines
Subjects:
biomarker
MRI
mass spectrometry
EV array
endothelial stress
blood brain barrier
Online Access:https://www.mdpi.com/2227-9059/11/12/3170

Internet

https://www.mdpi.com/2227-9059/11/12/3170

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