Interplay of adherens junctions and matrix proteolysis determines the invasive pattern and growth of squamous cell carcinoma

Interplay of adherens junctions and matrix proteolysis determines the invasive pattern and growth of squamous cell carcinoma

Cancers, such as squamous cell carcinoma, frequently invade as multicellular units. However, these invading units can be organised in a variety of ways, ranging from thin discontinuous strands to thick ‘pushing’ collectives. Here we employ an integrated experimental and computational approach to ide...

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Bibliographic Details
Main Authors: Takuya Kato, Robert P Jenkins, Stefanie Derzsi, Melda Tozluoglu, Antonio Rullan, Steven Hooper, Raphaël AG Chaleil, Holly Joyce, Xiao Fu, Selvam Thavaraj, Paul A Bates, Erik Sahai
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-03-01
Series:eLife
Subjects:
invasive pattern
tumour microenvironment
cellular mechanisms
computational modelling
Online Access:https://elifesciences.org/articles/76520

Internet

https://elifesciences.org/articles/76520

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