A therapeutic antibody against west nile virus neutralizes infection by blocking fusion within endosomes.

Defining the precise cellular mechanisms of neutralization by potently inhibitory antibodies is important for understanding how the immune system successfully limits viral infections. We recently described a potently inhibitory monoclonal antibody (MAb E16) against the envelope (E) protein of West N...

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Bibliographic Details
Main Authors: Bruce S Thompson, Bastiaan Moesker, Jolanda M Smit, Jan Wilschut, Michael S Diamond, Daved H Fremont
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-05-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2679195?pdf=render