Reconstruction of Ewing Sarcoma Developmental Context from Mass-Scale Transcriptomics Reveals Characteristics of EWSR1-FLI1 Permissibility

Reconstruction of Ewing Sarcoma Developmental Context from Mass-Scale Transcriptomics Reveals Characteristics of EWSR1-FLI1 Permissibility

Ewing sarcoma is an aggressive pediatric cancer of enigmatic cellular origins typically resulting from a single translocation event t (11; 22) (q24; q12). The resulting fusion gene, <i>EWSR1-FLI1</i>, is toxic or unstable in most primary tissues. Consequently, attempts to model Ewing sar...

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Bibliographic Details
Main Authors: Henry E. Miller, Aparna Gorthi, Nicklas Bassani, Liesl A. Lawrence, Brian S. Iskra, Alexander J. R. Bishop
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
Ewing sarcoma
EWSR1-FLI1
transcriptomics
manifold learning
single cell biology
R-loops
Online Access:https://www.mdpi.com/2072-6694/12/4/948

Internet

https://www.mdpi.com/2072-6694/12/4/948

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