Microglia Depletion Attenuates the Pro-Resolving Activity of the Formyl Peptide Receptor 2 Agonist AMS21 Related to Inhibition of Inflammasome NLRP3 Signalling Pathway: A Study of Organotypic Hippocampal Cultures

Microglia Depletion Attenuates the Pro-Resolving Activity of the Formyl Peptide Receptor 2 Agonist AMS21 Related to Inhibition of Inflammasome NLRP3 Signalling Pathway: A Study of Organotypic Hippocampal Cultures

Microglial cells have been demonstrated to be significant resident immune cells that maintain homeostasis under physiological conditions. However, prolonged or excessive microglial activation leads to disturbances in the resolution of inflammation (RoI). Formyl peptide receptor 2 (FPR2) is a crucial...

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Bibliographic Details
Main Authors: Kinga Tylek, Ewa Trojan, Monika Leśkiewicz, Imane Ghafir El Idrissi, Enza Lacivita, Marcello Leopoldo, Agnieszka Basta-Kaim
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Cells
Subjects:
formyl peptide receptor 2
ureidopropanamide agonist
neuroinflammation
lipopolysaccharide
inflammasome NLPR3-related pathway
hippocampus
Online Access:https://www.mdpi.com/2073-4409/12/21/2570

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https://www.mdpi.com/2073-4409/12/21/2570

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