Design, synthesis, anticancer evaluation, molecular docking and in silico ADME analysis of novel substituted 1,3,4-thiadazoloaryl incorporated pyrimidine-thiazole derivatives as propitious anticancer agents

Design, synthesis, anticancer evaluation, molecular docking and in silico ADME analysis of novel substituted 1,3,4-thiadazoloaryl incorporated pyrimidine-thiazole derivatives as propitious anticancer agents

A novel library of 1,3,4-thiadazoloaryl based pyrimidine-thiazole derivatives (10a-j) was synthesized and their chemical structures were confirmed by 1HNMR, 13CNMR, and mass spectral data. in silico ADME studies have demonstrated that all these compounds have a good pharmacokinetic profile. Further,...

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Bibliographic Details
Main Authors: Ramesh Boddiboyena, Gattu Sridhar, G. Nagendra Reddy, Nareshvarma Seelam, Monima Sarma, Deepti Kolli, Mura Reddy Gudisela
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Results in Chemistry
Subjects:
Dasatinib
1,3-Thiazoles
Acetazolamide
1,3,4-Thiadazole
SAR
Anticancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715624000304

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http://www.sciencedirect.com/science/article/pii/S2211715624000304

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