Design, synthesis, anticancer evaluation, molecular docking and in silico ADME analysis of novel substituted 1,3,4-thiadazoloaryl incorporated pyrimidine-thiazole derivatives as propitious anticancer agents

Design, synthesis, anticancer evaluation, molecular docking and in silico ADME analysis of novel substituted 1,3,4-thiadazoloaryl incorporated pyrimidine-thiazole derivatives as propitious anticancer agents

A novel library of 1,3,4-thiadazoloaryl based pyrimidine-thiazole derivatives (10a-j) was synthesized and their chemical structures were confirmed by 1HNMR, 13CNMR, and mass spectral data. in silico ADME studies have demonstrated that all these compounds have a good pharmacokinetic profile. Further,...

Ամբողջական նկարագրություն

Մատենագիտական մանրամասներ
Հիմնական հեղինակներ: Ramesh Boddiboyena, Gattu Sridhar, G. Nagendra Reddy, Nareshvarma Seelam, Monima Sarma, Deepti Kolli, Mura Reddy Gudisela
Ձևաչափ: Հոդված
Լեզու:English
Հրապարակվել է: Elsevier 2024-01-01
Շարք:Results in Chemistry
Խորագրեր:
Dasatinib
1,3-Thiazoles
Acetazolamide
1,3,4-Thiadazole
SAR
Anticancer
Առցանց հասանելիություն:http://www.sciencedirect.com/science/article/pii/S2211715624000304

Համացանց

http://www.sciencedirect.com/science/article/pii/S2211715624000304

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