A method for intuitively extracting macromolecular dynamics from structural disorder

Here, the authors present a hierarchical disorder model for the analysis of disorder in both crystal and cryo-EM structures. They apply their approach to several structures of three proteins, including SARS-CoV-2 proteins, and discuss mechanistic and dynamical implications.

Bibliographic Details
Main Authors: Nicholas M. Pearce, Piet Gros
Format: Article
Language:English
Published: Nature Portfolio 2021-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25814-x