DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

Breast cancer genomes have revealed a novel form of mutation showers (kataegis) in which multiple same-strand substitutions at C:G pairs spaced one to several hundred nucleotides apart are clustered over kilobase-sized regions, often associated with sites of DNA rearrangement. We show kataegis can r...

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Bibliographic Details
Main Authors: Benjamin JM Taylor, Serena Nik-Zainal, Yee Ling Wu, Lucy A Stebbings, Keiran Raine, Peter J Campbell, Cristina Rada, Michael R Stratton, Michael S Neuberger
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-04-01
Series:eLife
Subjects:
Hypermutation
DNA deamination
AID/APOBEC
Kataegis
Cancer
Cytidine deamination
Online Access:https://elifesciences.org/articles/00534

Internet

https://elifesciences.org/articles/00534

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