A microglial activity state biomarker panel differentiates FTD-granulin and Alzheimer’s disease patients from controls

A microglial activity state biomarker panel differentiates FTD-granulin and Alzheimer’s disease patients from controls

Abstract Background With the emergence of microglia-modulating therapies there is an urgent need for reliable biomarkers to evaluate microglial activation states. Methods Using mouse models and human induced pluripotent stem cell-derived microglia (hiMGL), genetically modified to yield the most oppo...

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Bibliographic Details
Main Authors: Ida Pesämaa, Stephan A. Müller, Sophie Robinson, Alana Darcher, Dominik Paquet, Henrik Zetterberg, Stefan F. Lichtenthaler, Christian Haass
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer
Biomarker
Frontotemporal Dementia
Microglial activity
Patient stratification
Therapeutic modulation
Online Access:https://doi.org/10.1186/s13024-023-00657-w

Internet

https://doi.org/10.1186/s13024-023-00657-w

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