Uniaxial cyclic stretch enhances osteogenic differentiation of OPLL-derived primary cells via YAP-Wnt/β-catenin axis

Uniaxial cyclic stretch enhances osteogenic differentiation of OPLL-derived primary cells via YAP-Wnt/β-catenin axis

The pathogenesis of posterior longitudinal ligament ossification (OPLL) remains inadequately understood. Mechanical stimulation is one of the important pathogenic factors in OPLL. As one of the mechanical stimulation transduction signals, the yes-associated protein (YAP) interacts with the Wnt/β-cat...

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Bibliographic Details
Main Authors: Z Zhu, T Tang, Z He, F Wang, H Chen, G Chen, J Zhou, S Liu, J Wang, W Tian, D Chen, X Wu, X Liu, Z Zhou
Format: Article
Language:English
Published: AO Research Institute Davos 2023-02-01
Series:European Cells & Materials
Subjects:
ossification of the posterior longitudinal ligament (opll)
mechanotransduction
heterotopic ossification
yes-associated protein (yap)
cytoskeleton remodelling
Online Access:https://www.ecmjournal.org/papers/vol045/pdf/v045a03.pdf

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https://www.ecmjournal.org/papers/vol045/pdf/v045a03.pdf

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